Lithium Hydroxide → HCID 66939434, compound

Participants

Reaction Conditions

Reaction Steps

The compound (1.2 g) obtained in Example 201b was dissolved in tetrahydrofuran (32 mL) and water (8 mL), and lithium hydroxide (0.56 g) was added. The reaction mixture was heated at 40-60° C. for 48 hr, stirred and concentrated under reduced pressure. The residue was diluted with water and adjusted with 2.5N hydrochloric acid to pH 5-6. The resulting precipitate was collected by filtration and dried. The obtained solid was recrystallized from ethyl acetate to give the title compound (0.60 g) as a colorless solid.

Provenance & Evidence