HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Methyl 4-(2-chloro-2-oxoethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(4-(Methoxycarbonyl)phenyl)acetic acid | HCID 10797879 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-(2-chloro-2-oxoethyl)benzoate | HCID 19746402 | — |
Reaction Steps
A solution of the compound (3.0 g) obtained in Example 206a in dichloromethane (50 mL) was cooled in an ice bath, and oxalyl chloride (3.93 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-f6db7af0968d4d169df79cf7eee4e942 |
| Source note | uspto-grants-2013_06 |