HCID 60166868, compound → HCID 67343618, compound

Participants

Reaction Steps

A solution of 3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (425 mg, 898 μmol) in THF (15 ml) containing palladium (10% on carbon, 95.0 mg, 90.0 μmol) was stirred at ambient temperature under a hydrogen atmosphere for 24 hours. The mixture was filtered through Celite®, the filter cake thoroughly washed with THF, and the combined filtrates concentrated under vacuum to give 498 mg of 3-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-azetidine-1-carboxylic acid tert-butyl ester, which was used without further purification. LCMS (Method B, ESI): RT=4.04 min, m+H=444.4.

Provenance & Evidence