Sodium Nitrite → HCID 178457827, compound

Participants

Reaction Steps

Sodium nitrite (12 mg, 0.17 mmol) was added to a solution of trans 4-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclohexanecarboxylic acid isopropylamide (70 mg, 0.15 mmol) in acetic acid (1 mL) and stirred for 45 minutes. The mixture was concentrated under vacuum affording trans 4-(6-benzenesulfonyl-6H-1,2,3,5,6-pentaaza-as-indacen-1-yl)-cyclohexanecarboxylic acid isopropylamide which was used for the next step without further purification. LCMS (Method B, ESI): RT=3.58 min, m+H=467.35.

Provenance & Evidence