Trifluoroacetic acid → HCID 87364290, compound

Participants

Reaction Steps

1-Benzenesulfonyl-N*4*-(1-benzyl-piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine (500 mg, 1.08 mmol) in TFA (5 mL) was heated to reflux for 5 hours. After cooling the mixture was concentrated under vacuum affording N-[1-benzenesulfonyl-4-(1-benzyl-piperidin-4-ylamino)-1H-pyrrolo[2,3-b]pyridine-5-yl]-2,2,2-trifluoro-acetamide as an orange residue which was used for the next step without further purification. LCMS (Method B, ESI): RT=2.68 min, m+H=558.35.

Provenance & Evidence