Chloroacetyl chloride → HCID 67347355, compound

Participants

Reaction Steps

To an ice-cold mixture of 1-benzenesulfonyl-N*4*-(1-benzyl-piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine 1.30 g, 2.80 mmol) and triethylamine (0.59 mL, 4.20 mmol) in DCM (50 mL) was added chloroacetyl chloride (0.25 mL, 3.10 mmol) and the mixture was stirred 2 h. The reaction mixture was diluted with DCM, washed with water, brine, and dried over sodium sulphate. The residue was purified by flash (silica gel. 0-5% MeOH/DCM) to afford N-[1-Benzenesulfonyl-4-(1-benzyl-piperidin-4-ylamino)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-chloro-acetamide (1.10 g, 72%): LCMS (method E, ESI): RT=1.2 min; m+1=538.2.

Provenance & Evidence