Water → HCID 67352516, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Acetic acid 3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclohexyl ester (trans racemic) (9.72 g, 21.2 mmol), ammonium chloride (2.26 g, 42.40 mmol), iron powder (5.92 g, 106 mmol), and water (15.0 mL) in ethanol (150 ml) was heated at 80° C. overnight. The reaction was followed by LC/MS to completion. On completion, the reaction mixture was used as is for the next step without any workup. LCMS (Method M, ESI): RT=1.90 min, m+H=428.9.

Provenance & Evidence