HCID 67345148, compound → HCID 67343253, compound

Participants

Reaction Steps

A mixture of 4-(6-benzenesulfonyl-2-methyl-6H-1,2,3,5,6-pentaaza-as-indacen-1-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (280 mg, 0.56 mmol)) in DCM/TFA was stirred for 1 hr. The solvent was evaporated under vacuum and the resulting residue purified by column chromatography (SCX-2, gradient: 0 to 50% [2M NH3 in methanol] in DCM) to afford 205 mg (93%) of 6-benzenesulfonyl-1-(4-methyl-piperidine-4-yl)1,6-dihydro-1,2,3,5,6-pentaaza-as-indacene. 1H NMR (400 MHz, DMSO): δ 9.25 (s, 1H), 8.19-8.17 (m, 3H), 7.76-7.72 (m, 1H), 7.65 (t, 2H), 7.48 (d, 1H), 2.83-2.80 (m, 4H), 2.55 (m, 2H), 2.00 (d, 2H), 1.82 (s, 3H).

Provenance & Evidence