Trifluoroacetic acid → racemic trans 3-(6-benzenesulfonyl-6H-1,2,3,5,6-pentaaza-as-indacen-1-yl)-cyclopentylamine

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Reaction Steps

A mixture of racemic trans [3-(6-benzenesulfonyl-6H-1,2,3,5,6-pentaaza-as-indacen-1-yl)-cyclopentyl]-carbamic acid tert-butyl ester (1.00 g, 2.07 mmol) and trifluoroacetic acid (4 mL) was stirred at ambient temperature for 90 minutes. The mixture was purified by column chromatography (SCX-2, gradient: methanol to 2M NH3 in methanol) to afford 600 mg (76%) of racemic trans 3-(6-benzenesulfonyl-6H-1,2,3,5,6-pentaaza-as-indacen-1-yl)-cyclopentylamine as an off white foam. LCMS (Method B, ESI): RT=2.40 min, m+H=383.

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