Trifluoroacetic acid → HCID 178511030, compound

Participants

Reaction Steps

A solution of trans [4-(2-cyano-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.68 g, 10.6 mmol) in DCM (30 mL) was treated with trifluoroacetic acid (30 mL) and the mixture was stirred at ambient temperature for 30 mins then concentrated under vacuum. The residue was azeotroped with toluene (×3) and the resulting oil was triturated (diethyl ether) to give a solid, that was washed with ether and dried to give 2.75 g (97%) of trans 3-(4-amino-cyclohexyl)-propionitrile trifluoroacetic acid salt as a white solid. 1H NMR (400 MHz, CDCl3) δ: 7.88 (br s, 3H), 3.01 (m, 1H), 2.37 (t, 2H), 2.08 (m, 2H), 1.89 (m, 2H), 1.59 (q, 2H), 1.49-1.35 (m, 3H), 1.04 (m, 2H).

Provenance & Evidence