Hydrochloric Acid → HCID 67344293, compound

Participants

Reaction Conditions

Reaction Steps

A 4.0 M solution of HCl in 1,4-dioxane (60 ml) was added to 3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (6.11 g, 12.2 mmol) dissolved in 1,4-dioxane (30 ml) at 25° C. The resulting suspension mixture was stirred at 50° C. for 2 h, then was cooled to 25° C. and was concentrated under reduced pressure. Toluene (80 ml) was added to the residue and the mixture was again concentrated under reduced pressure to give crude (1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-yl)-piperidin-3-yl-amine hydrochloride as a yellow solid. This material was used in the next step below without additional characterization or purification.

Provenance & Evidence