Sodium borohydride → HCID 23455863, compound

Participants

Reaction Steps

To a solution of 3-Azido-cyclopentanone (about 7.2 g, 57.6 mmol) in methanol (250 mL) was added sodium borohydride (11 g, 288 mmol) in five portions at 0° C., then the reaction mixture was stirred at room temperature for 1 hour. The resulting mixture was quenched with water and extracted with ethyl acetate. The organic solution (TLC showed one spot) was concentrated and the residue was used for the next step. 1H NMR (400 MHz, CDCl3) δ: 4.25-4.30 (m, 1H), 3.95-3.80 (m, 6H).

Provenance & Evidence