Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67019304 | HCID 67019304 | 98.3% |
Reaction Steps
A mixture of 2-fluoropyridine (1.0 g, 10.3 mmol) and tert-butyl pyrrolidin-3-ylcarbamate (1.80 g, 9.66 mmol) was heated at 120° C. for 5 h. After cooling to RT, the solid formed was treated with ether, filtered, and washed with ether. The solid was collected and dried to give the desired product (2.50 g, 98.2%). LCMS: (M+H)=264.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08461330B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-7e025b2e47604a7f964dbd25c7d2a3e6 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
