HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 4-(3-amino-1,2,4-triazin-6-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate | HCID 59216349 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 4-(3-amino-1,2,4-triazin-6-yl)benzoate | HCID 67225162 | — |
Reaction Steps
A solution of methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate (180 mg, 0.721 mmol) and 2M of ammonia in isopropyl alcohol (5 ml, 10 mmol) was stirred at 25° C. for 3 h. The reaction was diluted with water, and the precipitate was filtered to give the desired product. LCMS: (M+H2O+H)=249.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461330B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-2dea90a74064462b8b94bdd8fae4831b |
| Source note | uspto-grants-2013_06 |