Hydrochloric Acid → 6-[2-(1H-pyrazol-4-yl)imidazo[1,2-b][1,2,4]triazin-7-yl]methylquinoline

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	2-Chloro-3-(quinolin-6-yl)propanal	HCID 57516537	—
Reactant	6-[1-(1-Ethoxyethyl)-1H-pyrazol-4-yl]-1,2,4-triazin-3-amine	HCID 67224533	—
Solvent	Isopropanol	HCID 3776	—
Product	6-[2-(1H-pyrazol-4-yl)imidazo[1,2-b][1,2,4]triazin-7-yl]methylquinoline	HCID 136344847	64.2%

Reaction Conditions

Temperature	110 °C

Reaction Steps

A mixture of 6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1,2,4-triazin-3-amine (390.0 mg, 1.665 mmol) and 2-chloro-3-quinolin-6-ylpropanal (480 mg, 2.2 mmol) in isopropyl alcohol (20 mL) was heated at 110° C. for 2 days. After cooling to RT, 0.2 mL of concentrated HCl was added and stirred until completely deprotected. The solid formed was collected by filtration to give the desired product (0.35 g, 64%). LCMS: (M+H)=328.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08461330B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-448cb29d1fbb49b2bc6200d4a15dd7ae
Source note	uspto-grants-2013_06