HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1257909Generated: October 31, 2026
1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclopropanecarboxylic acid → HCID 67225167, compound
https://huagongshe.com/reaction/1257909
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclopropanecarboxylic acid | HCID 67224021 | — |
| Reactant | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 67225167 | HCID 67225167 | 31.3% |
Reaction Steps
A mixture of 1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclopropanecarboxylic acid (0.22 g, 0.86 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.21 g, 0.86 mmol) in ethanol (8 mL) was stirred at 100° C. overnight. The reaction mixture was purified by RP-HPLC (pH 10) to afford the desired product (0.12 g, 31%). LCMS: (M+H)=447.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08461330B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-214832c095b64822a77e78b10b739516 |
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| Source note | uspto-grants-2013_06 |
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