6-(4-Bromo-3-fluorophenyl)-1,2,4-triazin-3-amine → HCID 86621515, compound

HRID 1257915Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH2:14])=[N:10][CH:9]=2)=[CH:4][C:3]=1[F:15].[C:16]([O:20][C:21](=[O:34])[NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH:30](Cl)[CH:31]=O)[CH:24]=1)([CH3:19])([CH3:18])[CH3:17]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]3[N:12]([C:30]([CH2:29][C:25]4[CH:24]=[C:23]([NH:22][C:21](=[O:34])[O:20][C:16]([CH3:18])([CH3:17])[CH3:19])[CH:28]=[CH:27][CH:26]=4)=[CH:31][N:14]=3)[N:13]=2)=[CH:4][C:3]=1[F:15]

Participants

Conditions

Temperature: 105 °C

Procedure

A mixture of 6-(4-bromo-3-fluorophenyl)-1,2,4-triazin-3-amine (19 mg, 0.070 mmol) and tert-butyl[3-(2-chloro-3-oxopropyl)phenyl]carbamate (20 mg, 0.070 mmol) in ethanol (0.4 mL) was stirred overnight at 105° C. The reaction mixture was purified by RP-HPLC (pH 10) to afford the desired product. LCMS: (M+H)=498.0/500.0.

Workup

customThe reaction mixture was purified by RP-HPLC (pH 10)

Sources & evidence

ORD record: ord-c2cc414d48ca444f8ea99c099cfba4f8
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08461330B2

Reaction notes

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