HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid | HCID 66756524 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride | HCID 86654832 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid (100 g) and toluene (300 mL) were mixed, and thionyl chloride (47.5 g) and DMF (2.5 g) were added, followed by heating and stirring at 100° C. for 2 hours. After completion of the reaction, 180 mL of toluene was distilled off under reduced pressure to obtain a solution of 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466089B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-76bb08361f414ae1bac6777ec3398c82 |
| Source note | uspto-grants-2013_06 |