Hydrochloric Acid → HCID 86670535, compound

Participants

Reaction Conditions

Reaction Steps

A 100 mL vial equipped with stir bar was charged with tert-butyl 5′-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3′-oxospiro[azetidine-3,1′-isoindoline]-1-carboxylate (Preparation 21, 240 mg, 0.4 mmol) and anhydrous methanol (25 mL). A methanolic solution of HCl (1 mL of a 1.25M solution) was added and the reaction was heated to 65° C. for 6 hours. The reaction was cooled and concentrated under vacuum. The residue was rinsed with diethyl ether, concentrated under vacuum, and subsequently placed under high vacuum for 1 hour to afford the intermediate (216 mg, 95%) as an HCl salt. m/z (CI) 524 [M+H]+.

Provenance & Evidence