4-Fluorobenzoyl chloride → HCID 11750111, compound

HRID 1258052Notes

Reaction equation

HRID 1258052 reaction equation
[CH3:1][C:2]1([CH3:21])[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[C:6]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:5][NH:4][CH2:3]1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1>>[CH3:1][C:2]1([CH3:21])[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[C:6]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:5][N:4]([C:27](=[O:28])[C:26]2[CH:30]=[CH:31][C:23]([F:22])=[CH:24][CH:25]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 25121532Ethyl 1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 11750111HCID 11750111, compound

Procedure

As described in Example 2, the title compound was prepared from ethyl 1,1-dimethyl-1,2,3,6-tetrahydro-azepino[4,5-b]indole-5-carboxylate and 4-fluorobenzoyl chloride. 1H-NMR (DMSO-d6): δ 10.82 (1H, s), 7.76 (1H, d), 7.65 (1H, s), 7.61 (2H, dd), 7.54 (1H, d), 7.35 (2H, app t), 7.09 (1 H, app t), 6.98 (1 H, app t), 4.22 (2H, q), 3.97 (2H, brs), 1.52 (6H, s), 1.17 (3H, t); MS(ESI): 407 (MH+).

Sources & evidence

ORD record
ord-58e4cd99c8664aa8970ac4bc19496a1f
Source dataset
uspto-grants-2013_06
Patent number
US08466143B2

Reaction notes

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