3,4-Difluorobenzoyl chloride → HCID 25121184, compound

HRID 1258058Notes

Reaction equation

HRID 1258058 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:22][C:9]2[C:10]([C:17]([O:19][CH2:20]C)=[O:18])=[CH:11][NH:12][CH2:13][C:14]([CH3:16])([CH3:15])[C:8]=2[CH:7]=1)=[O:5])C.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][C:32]=1[F:33])[C:27](Cl)=[O:28]>>[CH3:1][O:3][C:4]([C:6]1[NH:22][C:9]2[C:10]([C:17]([O:19][CH3:20])=[O:18])=[CH:11][N:12]([C:27](=[O:28])[C:26]3[CH:30]=[CH:31][C:32]([F:33])=[C:24]([F:23])[CH:25]=3)[CH2:13][C:14]([CH3:16])([CH3:15])[C:8]=2[CH:7]=1)=[O:5]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 69436920HCID 69436920, compound

Product 1

HCID 25121184HCID 25121184, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2 by using 4,4-dimethyl-1,4,5,6-tetrahydro-pyrrolo[2,3-d]azepine-2,8-dicarboxylic acid diethyl ester and 3,4-difluoro-benzoyl chloride. 1H-NMR(CDCl3): δ 11.11 (1H, s), 7.83 (1H, s), 7.48 (1H, m), 7.36 (1H, m), 6.87 (1H, d), 4.33 (2H, q), 4.24 (2H, q), 3.89 (2H, s), 1.36 (3H, t), 1.33 (6H, s), 1.22 (3H, t). MS (ES): 447 (MH+).

Sources & evidence

ORD record
ord-1e9c3ce8c1594079ae79073fb5615ad3
Source dataset
uspto-grants-2013_06
Patent number
US08466143B2

Reaction notes

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