3,4-Difluorobenzoyl chloride → HCID 11397010, compound

HRID 1258059Notes

Reaction equation

HRID 1258059 reaction equation
[CH:1]([O:4][C:5]([C:7]1[C:13]2[NH:14][C:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:16][C:12]=2[C:11]([CH3:23])([CH3:22])[CH2:10][NH:9][CH:8]=1)=[O:6])([CH3:3])[CH3:2].[F:24][C:25]1[CH:26]=[C:27]([CH:31]=[CH:32][C:33]=1[F:34])[C:28](Cl)=[O:29]>>[CH:1]([O:4][C:5]([C:7]1[C:13]2[NH:14][C:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:16][C:12]=2[C:11]([CH3:23])([CH3:22])[CH2:10][N:9]([C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:33]([F:34])=[C:25]([F:24])[CH:26]=2)[CH:8]=1)=[O:6])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 69435568HCID 69435568, compound

Product 1

HCID 11397010HCID 11397010, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2 by using 4,4-dimethyl-1,4,5,6-tetrahydro-pyrrolo[2,3-d]azepine-2,8-dicarboxylic acid 2-ethyl ester 8-isopropyl ester and 3,4-difluoro-benzoyl chloride. 1H-NMR(CDCl3): δ 11.11 (1H, s), 7.83 (1H, s), 7.48 (1H, m), 7.27 (1H, m), 6.87 (1H, d), 5.10 (1H, m), 4.33 (2H, q), 3.92 (2H, s), 1.37 (3H, t), 1.33 (6H, s), 1.21 (6H, d). MS (ES): 461 (MH+).

Sources & evidence

ORD record
ord-65a1d6f78bf24595b616ffbbbd8c749a
Source dataset
uspto-grants-2013_06
Patent number
US08466143B2

Reaction notes

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