3,4-Difluorobenzoyl chloride → HCID 11363495, compound

HRID 1258060Notes

Reaction equation

HRID 1258060 reaction equation
[CH:1]([O:4][C:5]([C:7]1[C:13]2[N:14]([CH3:22])[C:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:16][C:12]=2[C:11]([CH3:24])([CH3:23])[CH2:10][NH:9][CH:8]=1)=[O:6])([CH3:3])[CH3:2].[F:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][C:34]=1[F:35])[C:29](Cl)=[O:30]>>[CH:1]([O:4][C:5]([C:7]1[C:13]2[N:14]([CH3:22])[C:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:16][C:12]=2[C:11]([CH3:24])([CH3:23])[CH2:10][N:9]([C:29](=[O:30])[C:28]2[CH:32]=[CH:33][C:34]([F:35])=[C:26]([F:25])[CH:27]=2)[CH:8]=1)=[O:6])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 69433972HCID 69433972, compound

Product 1

HCID 11363495HCID 11363495, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2 by using 1,4,4-trimethyl-1,4,5,6-tetrahydro-pyrrolo[2,3-d]azepine-2,8-dicarboxylic acid 2-ethyl ester 8-isopropyl ester and 3,4-difluoro-benzoyl chloride. 1H-NMR(CDCl3): δ 7.75 (1H, s), 7.43 (1H, m), 7.28 (2H, m), 6.86 (1H, d), 5.06 (1H, m), 4.28 (2H, q), 3.87 (2H, s), 3.66 (3H, s), 1.35 (3H, 3), 1.33 (6H, s), 1.21 (6H, d). MS (ES): 475 (MH+).

Sources & evidence

ORD record
ord-d4ead9e11f9d4e348576a5c932a21c63
Source dataset
uspto-grants-2013_06
Patent number
US08466143B2

Reaction notes

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