1-Butanol → HCID 28530649, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-amino-1-benzylpiperidine (4 g, 21 mmol) and 3,6-dichloro-pyridazine (1.56 g, 10.5 mmol) was stirred for 1 h at 120° C., before n-butanol (10 ml) was added and the reaction mixture stirred for a further 1 h at 120° C. After addition of water and dichloromethane, the organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo. The residue was crystallized from acetonitrile and the resulting solid was filtered off and dried to yield D1 (1.3 g, 41%) as a solid. C16H19ClN4 requires 302. Found 303 (MH+); mp: 208.2-209.3° C.

Provenance & Evidence