反应详情

温度

160 °C

A mixture of D10 (0.225 g, 0.84 mmol), copper cyanide (0.15 g, 1.67 mmol) in acetonitrile (2 ml) was stirred at 160° C. for 20 min., under microwave irradiation. Dichloromethane was then added and the mixture filtered over celite. The solvent was evaporated in vacuo and the residue purified by column chromatography (silica gel; dichloromethane/heptane 1:1 to 7:3) to yield D11 (0.120 g, 85%) as a solid. C7H6ClN3 requires 167. Found 166 (MH−).

1. filtrationthe mixture filtered over celite
2. customThe solvent was evaporated in vacuo
3. customthe residue purified by column chromatography (silica gel; dichloromethane/heptane 1:1 to 7:3)