HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → trans-1-Acetamido-2-indanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (1R,2S)-(+)-cis-1-Amino-2-indanol | HCID 2725045 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | trans-1-Acetamido-2-indanol | HCID 15760043 | — |
Reaction Steps
(1R,2S)-1-amino-2-indanol (2.0 g) is suspended in 100 mL CH2Cl2 and at RT combined with acetic anhydride (1.27 mL). The reaction mixture is stirred for 1 h at RT. After the reaction has ended the solvent is eliminated using the rotary evaporator and the crude product (HPLC-MS: tRet.=0.81 min; MS (M+H)+=192) is used in subsequent reactions without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466155B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-5a9285729ef545319d8480fb7a72eb63 |
| Source note | uspto-grants-2013_06 |