HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258190Generated: October 26, 2026
Water → 4-(6-Nitroindol-1-yl)benzoic acid ethyl ester
https://huagongshe.com/reaction/1258190
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Reactant | 6-Nitro-1H-indole | HCID 78502 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(6-Nitroindol-1-yl)benzoic acid ethyl ester | HCID 58437219 | 66.9% |
Reaction Steps
To a solution of 6-nitro-1H-indole (0.5 g) in N,N-dimethylformamide (10 mL) were added cesium carbonate (1.2 g) and 4-fluoro benzoic acid ethyl ester (0.62 g), and this mixture was stirred at 75° C. overnight. This reaction mixture was poured into water and the precipitated solid was collected by filtration, and washed with water and n-hexane, dried under reduced pressure to give the title compound (0.64 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08466152B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-e0d00406b1154f3ba7b1e5370ba57795 |
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| Source note | uspto-grants-2013_06 |
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