HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258228Generated: October 25, 2026
Potassium Phosphate, Tribasic → 2-(3-Cyanoindol-1-yl)isonicotinic acid ethyl ester
https://huagongshe.com/reaction/1258228
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 3-Cyanoindole | HCID 230282 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | Ethyl 2-bromoisonicotinate | HCID 3847769 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(3-Cyanoindol-1-yl)isonicotinic acid ethyl ester | HCID 58437311 | 30.1% |
Reaction Steps
A mixture of 1H-indole-3-carbonitrile (0.1 g), 2-bromoisonicotinic acid ethyl ester (0.16 g), potassium phosphate (0.27 g), (1R,2R)-(−)-N,N′-dimethylcyclohexane-1,2-diamine (0.017 g), copper iodide (0.006 g) and toluene (0.7 mL) was stirred at 110° C. for 38 hours. The insoluble material was removed by filtration, and this filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane=10/90 to 66/34) to give the title compound (0.061 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08466152B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-89d5616bbad54741beea848460d42c42 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
