2-Thiophenesulfonamide → 2-Thiophenesulfonamide

HRID 1258371Notes

Reaction equation

HRID 1258371 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH2:9])(=[O:8])=[O:7].C1(C2C=CC=CC=2)C=CC(S([Cl:19])(=O)=O)=CC=1>>[Cl:19][C:5]1[S:1][C:2]([S:6]([NH2:9])(=[O:8])=[O:7])=[CH:3][CH:4]=1.[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH2:9])(=[O:8])=[O:7]

Participants

4

Reactant 2

HCID 728812-ThiophenesulfonamideHCID 74192(1,1'-Biphenyl)-4-sulphonyl chloride

Product 2

HCID 728812-ThiophenesulfonamideYield 94.4%HCID 12413015-Chlorothiophene-2-Sulfonamide

Procedure

5-chlorothiophene-2-sulfonamide was prepared according to the procedure for thiophene-2-sulfonamide YG1-030 except using 4-biphenylsulfonyl chloride, which afforded the title compound 932.5 mg (94.4%) as a white solid, m.p.: 110-112° C.

Sources & evidence

ORD record
ord-92042eaee7034ddd971ed180e7a32b81
Source dataset
uspto-grants-2013_06
Patent number
US08466157B2

Reaction notes

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