Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylsulfonyl)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | (NE)-N-(3-chloro-4-oxonaphthalen-1-ylidene)thiophene-2-sulfonamide | HCID 22524852 | — |
| 반응물 | N-(3-ethoxy-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide | HCID 67330544 | — |
| 생성물 | 2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylsulfonyl)acetic acid | HCID 44608991 | 28.8% |
반응 단계
5.2.36 N-(3-ethoxy-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide (13a): 33.8 mg (E)-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide was suspended in 2 ml ethanol, to which was added 0.5 ml sodium ethoxide in ethanol solution (0.2 M). The suspension disappeared and in 5 min it turned cloudy with yellow precipitate. The resulting reaction mixture was concentrated and the crude product was purified by flash column (EtOAc/Hex) affording the title compound 10 mg (28.8%) as a bright yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08466157B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-992bd71c870d4c1e9d416e699f699337 |
| 출처 메모 | uspto-grants-2013_06 |