HRID1258393

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1C(SCCO)=CC(=NS(=O)(=O)c2cccs2)c2ccccc21

HCID67330679

未命名化合物

结构：Cn1nnnc1Sc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1O

HCID135895396

未命名化合物

PRODUCTS

生成物

结构：O=S(=O)(Nc1cc(SCCO)c(O)c2ccccc12)c1cccs1

HCID46908187

未命名化合物

HCID135895396

未命名化合物

收率 53.1%

PROCEDURE

实验过程

N-(4-hydroxy-3-(2-hydroxyethylthio)naphthalen-1-yl)thiophene-2-sulfonamide (14k) was prepared according to the procedure for 14d except using N-(3-(2-hydroxyethylthio)-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide (13k), which, after purification via flash chromatography (Hex/EtOAc), afforded the title compound 20.3 mg (53.1%) as a grey solid, m.p.: ° C.

WORKUP

后处理

customafter purification via flash chromatography (Hex/EtOAc)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-756bcc9f546e4df2b821732c1470d85f
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08466157B2
来源说明: uspto-grants-2013_06

反应 SMILES

[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][S:13]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)(=[O:15])=[O:14])=[CH:4][C:3]=1[S:21][C:22]1[N:26]([CH3:27])[N:25]=[N:24][N:23]=1.[OH:28][CH2:29][CH2:30][S:31][C:32]1[C:41](=[O:42])[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34](=[N:43][S:44]([C:47]2[S:48][CH:49]=[CH:50][CH:51]=2)(=[O:46])=[O:45])[CH:33]=1>>[OH:42][C:41]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]([NH:43][S:44]([C:47]2[S:48][CH:49]=[CH:50][CH:51]=2)(=[O:46])=[O:45])=[CH:33][C:32]=1[S:31][CH2:30][CH2:29][OH:28].[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][S:13]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)(=[O:15])=[O:14])=[CH:4][C:3]=1[S:21][C:22]1[N:26]([CH3:27])[N:25]=[N:24][N:23]=1