HRID1258413

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：Cn1nnnc1SC1=C/C(=N\S(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2C1=O$

HCID46908285

未命名化合物

结构：Cn1nnnc1Sc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1O

HCID135895396

未命名化合物

PRODUCTS

生成物

$结构：Cn1nnnc1SC1=C/C(=N\S(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2C1=O$

HCID46908285

未命名化合物

收率 82.3%

结构：Cn1nnnc1Sc1cc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2c1O

HCID135889305

未命名化合物

PROCEDURE

实验过程

N-(4-hydroxy-3-(1-methyl-1H-tetrazol-5-ylthio)naphthalen-1-yl)biphenyl-4-sulfonamide (14x) was prepared according to the procedure for 14d except using 13x, which afforded the title compound 33.0 mg (82.3%) as an off-white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7c3d7bf141714ec5b71b086766e24b0d
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08466157B2
来源说明: uspto-grants-2013_06

反应 SMILES

OC1C2C(=CC=CC=2)C(NS(C2SC=CC=2)(=O)=O)=CC=1SC1N(C)N=NN=1.[CH3:28][N:29]1[C:33]([S:34][C:35]2[C:44](=[O:45])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)/[C:37](=[N:46]/[S:47]([C:50]3[CH:55]=[CH:54][C:53]([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=4)=[CH:52][CH:51]=3)(=[O:49])=[O:48])/[CH:36]=2)=[N:32][N:31]=[N:30]1>>[OH:45][C:44]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[C:37]([NH:46][S:47]([C:50]2[CH:51]=[CH:52][C:53]([C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=3)=[CH:54][CH:55]=2)(=[O:49])=[O:48])=[CH:36][C:35]=1[S:34][C:33]1[N:29]([CH3:28])[N:30]=[N:31][N:32]=1.[CH3:28][N:29]1[C:33]([S:34][C:35]2[C:44](=[O:45])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)/[C:37](=[N:46]/[S:47]([C:50]3[CH:55]=[CH:54][C:53]([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=4)=[CH:52][CH:51]=3)(=[O:48])=[O:49])/[CH:36]=2)=[N:32][N:31]=[N:30]1