HRID1258414

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：Cn1nnnc1SC1=C/C(=N\S(=O)(=O)c2ccc(Cl)cc2)c2ccccc2C1=O$

HCID46908286

未命名化合物

结构：Cn1nnnc1Sc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1O

HCID135895396

未命名化合物

PRODUCTS

生成物

$结构：Cn1nnnc1SC1=C/C(=N\S(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2C1=O$

HCID46908285

未命名化合物

收率 99.3%

结构：Cn1nnnc1Sc1cc(NS(=O)(=O)c2ccc(Cl)cc2)c2ccccc2c1O

HCID135889307

未命名化合物

PROCEDURE

实验过程

4-chloro-N-(4-hydroxy-3-(1-methyl-1H-tetrazol-5-ylthio)naphthalen-1-yl)benzenesulfonamide (14y) was prepared according to the procedure for 14d except using 13y, which afforded the title compound 40.0 mg (99.3%) as an off-white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-78e57c6f0aef4a89be956117307f026a
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08466157B2
来源说明: uspto-grants-2013_06

反应 SMILES

O[C:2]1[C:11]2[C:6](=CC=CC=2)[C:5](NS(C2SC=CC=2)(=O)=O)=[CH:4][C:3]=1SC1N(C)N=NN=1.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](/[N:38]=[C:39]2\[CH:40]=[C:41]([S:50][C:51]3[N:55]([CH3:56])[N:54]=[N:53][N:52]=3)[C:42](=[O:49])[C:43]3[C:48]\2=[CH:47][CH:46]=[CH:45][CH:44]=3)(=[O:37])=[O:36])=[CH:31][CH:30]=1>>[Cl:28][C:29]1[CH:30]=[CH:31][C:32]([S:35]([NH:38][C:39]2[C:48]3[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=3)[C:42]([OH:49])=[C:41]([S:50][C:51]3[N:55]([CH3:56])[N:54]=[N:53][N:52]=3)[CH:40]=2)(=[O:37])=[O:36])=[CH:33][CH:34]=1.[CH3:56][N:55]1[C:51]([S:50][C:41]2[C:42](=[O:49])[C:43]3[C:48](=[CH:47][CH:46]=[CH:45][CH:44]=3)/[C:39](=[N:38]/[S:35]([C:32]3[CH:33]=[CH:34][C:29]([C:2]4[CH:11]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[CH:30][CH:31]=3)(=[O:37])=[O:36])/[CH:40]=2)=[N:52][N:53]=[N:54]1