HCID 178436954, compound → 6-Ethylpyrimidin-4-ol

HRID 1258416Notes

Reaction equation

HRID 1258416 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[C:4](S)[N:3]=1>O.[Ni]>[CH2:8]([C:6]1[N:5]=[CH:4][NH:3][C:2](=[O:1])[CH:7]=1)[CH3:9]

Participants

4

Reactant 1

HCID 178436954HCID 178436954, compound

Product 1

HCID 1354076886-Ethylpyrimidin-4-ol

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 962WaterSolvent

Procedure

90 g (0.58 mol) 4-Hydroxy-2-mercapto-6-ethylpyrimidine and 270 g Raney-Nickel are suspended in water (1000 mL) and the suspension is heated and stirred under reflux over night. The reaction mixture is filtered over celite and the filtrate is concentrated under reduced pressure to give crude product. Yield: 70.0 g (98%).

Workup

  1. temperaturethe suspension is heated
  2. temperatureunder reflux over night
  3. filtrationThe reaction mixture is filtered over celite
  4. concentrationthe filtrate is concentrated under reduced pressure
  5. customto give crude product

Sources & evidence

ORD record
ord-372ab541630b4a198ab5613e9135dd25
Source dataset
uspto-grants-2013_06
Patent number
US08466162B2

Reaction notes

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