HCID 24957971, compound → HCID 24958345, compound

Participants

Reaction Steps

6-[4-Methoxy-3-(2-methoxy-ethoxymethoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)-1H-furo[2,3-d]pyrimidin-2-one (Example 6) (102 mg, 0.2 mmol) was dissolved in mixture of THF (2 ml) and MeOH (2 ml) and 0.2 ml of concentrated HCl was added slowly with stirring. The reaction mixture was stirred for overnight with slow evaporation of solvents. The residue was dissolved in EtOAc (50 ml) and washed with water (5 ml). The organic layer was concentrated and purified by silica gel column chromatography using increasing gradient of EtOAc in CH2Cl2 and finally with 5% MeOH in 1:1 mixture of EtOAc and CH2Cl2. Yield (42%); 1H NMR (300 MHz, DMSO-d6) δ: 3.69 (s, 9H, 3×OMe), 3.75 (s, 3H, OMe), 6.71 (s, 2H), 6.92-7.11 (m, 3H), 8.15 (s, 1H).

Provenance & Evidence