HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 72280550, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(1-Piperidinyl)-2-butenoic acid | HCID 54109381 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 72280550 | HCID 72280550 | — |
Reaction Steps
The HCl salt of 4-Piperidin-1-yl-but-2-enoic acid (250 mg, 1.48 mmol) was dissolved in dichloromethane (15 mL). Dimethylformamide (3 drops) was added. Oxalyl chloride (155 μL, 1.77 mmol) was added slowly and the reaction was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was used as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466165B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-1bfe9cf3067b4ac291a15040699bd326 |
| Source note | uspto-grants-2013_06 |