2-(Methylamino)ethanol → HCID 59197940, compound

HRID 1258462Notes

Reaction equation

HRID 1258462 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2[C:10]3[O:11][CH:12]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:13][CH2:14][C:15]=3[C:16]([C:18](O)=[O:19])=[CH:17][C:8]=2[N:7]=[C:6]1[CH3:27].[CH3:28][NH:29][CH2:30][CH2:31][OH:32]>>[OH:32][CH2:31][CH2:30][N:29]([CH3:28])[C:18]([C:16]1[C:15]2[CH2:14][CH2:13][CH:12]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[O:11][C:10]=2[C:9]2[N:5]([CH2:4][CH2:3][O:2][CH3:1])[C:6]([CH3:27])=[N:7][C:8]=2[CH:17]=1)=[O:19]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 67220219HCID 67220219, compound

Product 1

HCID 59197940HCID 59197940, compound

Procedure

The title compound was prepared as a white solid in quantitative yield from 1-(2-methoxyethyl)-2-methyl-8-phenyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylic acid (200 mg, 0.55 mmol, Step 12 of Example 1) and 2-(methylamino)ethanol (45 mg, 0.60 mmol) by the same manner in Step 13 of Example 1.

Sources & evidence

ORD record
ord-30b01e3deedb4bb5bea567cf22c68e37
Source dataset
uspto-grants-2013_06
Patent number
US08466166B2

Reaction notes

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