Pyrrolidine → HCID 67220588, compound

Participants

Reaction Steps

To a solution of 1-(2,4-difluorophenyl)ethanone (10.0 g, 64.0 mmol) and pyrrolidine (32.1 mL, 384 mmol) in hexane (150 mL) was added titanium tetrachloride (3.86 mL, 35.2 mmol) dropwise at 0° C. over 15 minutes. The reaction mixture was stirred at room temperature for 24 hours and filtered. The filtrate was evaporated in vacuo to give pale yellow oil, which was distilled under reduced pressure (0.3 mmHg, 90-120° C.) to give the title compound as a pale yellow oil (4.90 g, 36%).

Provenance & Evidence