Phenyl Isothiocyanate → HCID 58338482, compound

Participants

Reaction Steps

350 mg of (1H-pyrrolo[2,3-b]pyridine-3-carbohydrazide and 261 μl of phenyl isothiocyanate in 10 ml of dichloroethane are stirred at 60° C. for 15 hours in a screw-lid vial. A further 78 μl of phenyl isothiocyanate are added, and the mixture is stirred at the same temperature for 20 hours. After cooling in the refrigerator, the precipitate is filtered off with suction and dried, giving 610 mg of 1-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-4-phenylthiosemicarbazide as colourless powder; (yield 98.6%); MS-FAB (M+H+)=312.3; Rf (polar method): 1.43 min.

Provenance & Evidence