HCID 22929965, compound → HCID 86650835, compound

HRID 1258504Notes

Reaction equation

HRID 1258504 reaction equation
CNC(C1C=C2C(=CC=1OCC)CN=C2N)=[O:4].Br[CH2:19][C:20]([C:22]1[CH:23]=[C:24]([NH:34][C:35](=[O:40])[C:36]([F:39])([F:38])[F:37])[CH:25]=[C:26]([S:28]([F:33])([F:32])([F:31])([F:30])[F:29])[CH:27]=1)=[O:21]>>[F:37][C:36]([F:39])([F:38])[C:35]([OH:40])=[O:4].[NH2:34][C:24]1[CH:23]=[C:22]([C:20](=[O:21])[CH3:19])[CH:27]=[C:26]([S:28]([F:33])([F:29])([F:30])([F:31])[F:32])[CH:25]=1

Participants

3

Reactant 2

HCID 22929965HCID 22929965, compoundHCID 58085702HCID 58085702, compound

Product 1

HCID 86650835HCID 86650835, compoundYield 72.1%

Procedure

N-Methyl-3-amino-6-ethoxy-1H-isoindole-5-carboxamide (30 mg, purchased from Chembiotek) was reacted with N-[3-(2-bromoacetyl)-5-pentafluorosulfanylphenyl]-2,2,2-trifluoroacetamide (50 mg) analogously to example 3b). 31 mg of the desired compound were obtained.

Sources & evidence

ORD record
ord-a354630a03c54aab961c107a1924c85d
Source dataset
uspto-grants-2013_06
Patent number
US08466169B2

Reaction notes

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