Sodium Iodide → N-Methoxy-N-methyl-3-morpholin-4-yl-5-(pentafluorosulfanyl)benzamide

Participants

Reaction Conditions

Reaction Steps

3-Amino-N-methoxy-N-methyl-5-(pentafluorosulfanyl)benzamide (6.3 g, example 4b) was dissolved in DMF (80 ml), and cesium carbonate (10.1 g), sodium iodide (0.62 g) and bis(2-bromoethyl)ether (19.37 g) were added. The mixture was divided between 10 microwave vessels, each of which was heated in the microwave to 130° C. for 3 h. Subsequently, the batches were combined and freed of the solvent. The residue was taken up in EA and washed with water. The EA phase was dried and concentrated. The residue was purified using silica gel (120 g cartridge, n-heptane/EA gradient of 0-100% within 30 min). 2.48 g of the title compound were obtained.

Provenance & Evidence