3-Nitroaniline → HCID 531958, compound

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Reaction Steps

3-Nitro-phenylamine (5 g, 36.2 mmol) was dissolved in a biphasic mixture of ethyl acetate (100 ml) and aqueous sodium hydrogen carbonate (1N) (100 ml). 4-Fluoro-benzoyl-chloride (8.7 ml, 41.6 mmol) was added under vigorous stirring. The mixture was stirred for 2 hours at ambient temperature. The phases were separated, the organic phase was dried over sodium sulfate and concentrated. The residue was used without further purification (9.4 g, 100% yield). 1H-NMR (CDCl3, 400 MHz) as disclosed in Magnetic Resonance in Chemistry (1997), 35(8), 543-548.

Provenance & Evidence