Hexanoyl chloride → HCID 86653135, compound

Participants

Reaction Steps

To a solution of 1-{6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}methanamine (0.21 g, 0.649 mmol, 1 eq.) in 2 ml of DCM was added TEA (0.197 g, 1.94 mmol, 3 eq.) followed by hexanoyl chloride (0.131 g, 0.974 mmol, 1.5 eq.). The reaction was stirred 4 h at room temperature and the solvent was evaporated. The crude was purified by chromatography on silica gel to give N-({6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}methyl)hexanamide (0.182 g, 62% yield) as a white solid.

Provenance & Evidence