1,1'-Thiocarbonyldi-2(1H)-pyridone → tert-Butyl 4-chloro-3-isothiocyanatobenzylcarbamate

Participants

Reaction Steps

Tert-butyl 3-amino-4-chlorobenzylcarbamate (2.57 g, 10.0 mmol) was added to a mixture of 1,1′-thiocarbonyldi-2-pyridone (2.55 g, 11.0 mmol) and DCM (90 mL) and it was stirred at rt for 4 h. The mixture was diluted with DCM and filtered over silica gel. The organic layer was concentrated to give the sub-title compound.

Provenance & Evidence