HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258628Generated: October 27, 2026
Tetrahydrofuran → 5-Chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline
https://huagongshe.com/reaction/1258628
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline | HCID 44120642 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline | HCID 67957692 | — |
Reaction Steps
A mixture of 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline (250 mg, 0.7 mmol), THF (6 mL), MeOH (6 mL) and Pt/C (50 mg) was stirred for 4 h at 35° C. under a hydrogen atmosphere (3.2 bar). The catalyst was removed by filtration and the mixture was concentrated to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08466186B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-71f6b0c2434641a285de8a63bb4fc3f4 |
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| Source note | uspto-grants-2013_06 |
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