N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide → N-(3-amino-4-chlorobenzyl)pivalamide

Participants

Reaction Steps

A mixture of N-(4-chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide (5.92 g, 21.9 mmol), THF (150 mL) and Ra—Ni (1.50 g) was stirred for 2 days at RT under a hydrogen atmosphere (3.0 bar). The catalyst was removed by filtration and the mixture was concentrated. The crude was purified by chromatography to give the sub-title compound.

Provenance & Evidence