HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(5-Aza-spiro[2.4]hept-5-yl)-4-chloro-2-nitro-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,5-Dichloro-2-nitroaniline | HCID 81149 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | 5-Azaspiro(2.4)heptane | HCID 21923103 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-(5-Aza-spiro[2.4]hept-5-yl)-4-chloro-2-nitro-phenylamine | HCID 67958543 | — |
Reaction Steps
The sub-title compound was prepared from 4,5-dichloro-2-nitroaniline (470 mg, 2.3 mmol), 5-aza-spiro[2.4]heptane (320 mg, 3.3 mmol) and potassium carbonate (470 mg, 3.4 mmol) in DMSO (5 mL) in analogy to example 3, step (a). Yield: 550 mg (91%). Rf(TLC): 0.85 (silica gel, DCM:EtOH 99:1). HPLC-method F: Rf=1.01 min. MS m/z: 533 [2M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-093557cfba954537963d9648d837166c |
| Source note | uspto-grants-2013_06 |