Aluminium lithium hydride → 3-(Aminomethyl)-2,6-dichloroaniline

Participants

Reaction Steps

3-Amino-2,4-dichloro-benzamide (2.00 g, 9.8 mmol) in THF (45 mL) was added dropwise to LiAlH4 (1 M in THF, 24.4 mL) in THF (45 mL). The reaction mixture was stirred for 1 h at rt and 10 h at reflux. Excess LiAlH4 was carefully destroyed under cooling as described by L. F. Fieser & M. Fieser Vol 1, p 584 Wiley 1967. After 30 min the mixture was filtered and the filtrate was concentrated to give the sub-title compound.

Provenance & Evidence