1,1'-Thiocarbonyldi-2(1H)-pyridone → N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamide

Participants

Reaction Steps

1,1′-Thiocarbonyldi-2-pyridone (4.87 g, 21 mmol) was added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide (5.50 g, 20 mmol) and dioxane (200 mL) and stirred at rt for 2 h and at reflux for 8 h. The mixture was concentrated, diluted with DCM and filtered over silica gel. The filtrate was concentrated to give the sub-title compound.

Provenance & Evidence