HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-5-(2-dimethylaminomethyl-pyrrolidin-1-yl)-benzene-1,2-diamine → HCID 178483242, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-5-(2-dimethylaminomethyl-pyrrolidin-1-yl)-benzene-1,2-diamine | HCID 67957762 | — |
| Reactant | tert-Butyl 4-chloro-3-isothiocyanatobenzylcarbamate | HCID 86646335 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178483242 | HCID 178483242 | — |
Reaction Steps
(4-Chloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester (68 mg, 0.2 mmol) followed by TEA (160 μL, 1.2 mmol) were added to 4-chloro-5-(2-dimethylaminomethyl-pyrrolidin-1-yl)-benzene-1,2-diamine (95 mg) in DMF (3 mL). The mixture was stirred at rt for 4 h and then purified by chromatography to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9a40ec4ec65b4c0192e74f4338b6d80d |
| Source note | uspto-grants-2013_06 |